Osteogenesis in adults

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Maintaing Health. During the Adult Years. Introduction. Osteogenesis imperfecta (OI) is a genetic disorder characterized by bones that break easily, often from little or no apparent trauma. It is caused by a genetic defect that affects the body’s production of type I collagen, which is the major protein in connective tissue.

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Adults with Osteogenesis Imperfecta. Osteogenesis imperfecta is a heritable disorder caused by mutations in the gene for type I collagen. The Sillence classification of osteogenesis imperfecta (types I through IV) is based on clinical characteristics. Whole-body images of adults with osteogenesis imperfecta who were recruited for a clinical trial Cited by: 4.


Osteogenesis imperfecta (OI) is the most common inherited disease that causes bone fragility, occurring with a frequency of 1 in 5, to 1 in 10, births (1). Feb 03, · Osteogenesis imperfecta (OI) is the most common inherited disease that causes bone fragility, occurring with a frequency of 1 in 5, to 1 in 10, Cited by:
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Osteogenesis imperf ecta in adults Nick J. Bishop 1 and Jennifer S. Walsh 2 1 Department of Human Metabolism, University of Sheffield, Sheffield, United Kingdom.

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Osteogenesis imperfecta (OI) is an inherited connective tissue disorder with many phenotypic presentations. It is often called "brittle bone disease." Severely affected patients suffer multiple fractures with minimal or no trauma, and infants with the worst form of OI die in the perinatal period. Osteogenesis imperfecta (OI) is a genetic disease whose clinical phenotype and severity vary considerably. The increased risk of fractures due to bone fragility persists in adulthood, notably after 40 years of age, albeit at a lower level than during growth.

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